Study of the Effect of Gamma Radiation on Plasma Levels of Copper and Manganese in Nuclear Medicine Staff

Introduction: Gamma radiations have used frequently at medical radiation centers for treatment of different cancers. This study aimed to consider possible alterations in level of serum zinc and selenium among nuclear medicine staff. Materials and Methods: This cross sectional study was carried out on 30 nuclear medicine staff and 10 individuals as control group. After collection of 20 cc blood samples, serum specimens were isolated by centrifuge at 4000 rpm for 7 min and then used for measurement of copper (Cu) and manganese (Mn). Copper and manganese were measured using atomic absorption spectroscopy (AAA) with graphite furnace. Results: The mean age of individuals in control and gamma radiated groups were 37 ± 5.77 and 41.83 ± 10.38, respectively (p=0.171). The mean of Cu in the control group (93.85±25.33) was approximately, but not significant (p=0.32) higher than that in radiated group (85.6±21.66). Increased duration of exposure was significantly associated with reduced Cu levels (p=0.05). Conclusion: Declined level of Cu can be considered as one of the possible mechanisms of gamma radiation effect on cells which may be associated with oxidative damages. Therefore, antioxidant therapy can be helpful for people who work at medical radiation centers; however, it merits further studies.